Endolex 25 mg Oral Solution 10 Sachets

Endolex is a medicine with analgesic action within the group of medicines known as NSAIDs, i.e. non-steroidal anti-inflammatory drugs.

It is indicated for the treatment of acute pain of mild to moderate intensity. For example, it is recommended in cases such as muscle pain, joint pain, menstrual pain or dental pain.

Endolex is a medicine that is indicated for adults over 18 years of age.

Endolex 25mg oral solution, as the name suggests, is an oral dosage form for swallowing. The tablets should be taken with water to make them easier to swallow. Depending on the intensity of the pain or the duration of the pain, the dose to be taken or the treatment will vary. However, it is advisable to take the lowest effective dose for the shortest time necessary.

That is, 1 sachet every 8 hours. Up to a maximum of 3 sachets per day.

If you are allergic to dexketoprofen or to any of the other ingredients of this medicinal product (listed in section 6);

• If you are allergic to acetylsalicylic acid or to another non-steroidal anti-inflammatory drug;
• If you have asthma or have had asthma attacks, acute allergic rhinitis (a short period of swelling of the lining of the nose), nasal polyps (fleshy formations inside the nose due to allergy), urticaria (skin rash), angioedema (swelling of the nose), allergic rhinitis (a short period of swelling of the mucous membrane of the nose), allergic rhinitis (a short period of swelling of the mucous membrane of the nose), urticaria (skin rash).(swelling of the face, eyes, lips or tongue, or difficulty breathing) or wheezing in the chest after taking aspirin or other non-steroidal anti-inflammatory drugs;
• If you have had photoallergic or phototoxic reactions (special form of redness or burning of skin exposed to sunlight) while taking ketoprofen (a non-steroidal anti-inflammatory drug) or fibrates (medicines used to reduce blood fat levels);
• If you have peptic ulcer, stomach or intestinal bleeding, or if you have had bleeding, ulceration or perforation of the stomach or intestine in the past;
• If you have chronic digestive problems (e.g. indigestion, heartburn);
• If you have had stomach or intestinal bleeding or perforation in the past, due to previous use of non-steroidal anti-inflammatory drugs (NSAIDs) used for pain;
• If you have chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis);
• If you have severe heart failure, moderate to severe kidney failure or severe liver failure;
• If you have bleeding disorders or blood clotting disorders;
• If you are severely dehydrated (have lost a lot of body fluid) due to vomiting, diarrhoea or insufficient fluid intake;
• If you are in the third trimester of pregnancy or breast-feeding.

Like all medicines, this medicine can cause side effects, although not everybody gets them. The possible side effects are listed below according to their frequency.

Common side effects (may affect up to 1 in 10 people):

• Nausea and/or vomiting, mainly upper quadrant abdominal pain, diarrhoea, digestive disorders (dyspepsia).
• Rare adverse effects (may affect up to 1 in 100 people):
• Rotatory sensation (vertigo), dizziness, drowsiness, sleep disturbances, nervousness, headache, palpitations, hot flushes, inflammation of the stomach wall (gastritis), stomach wall inflammation (gastritis).(gastritis), constipation, dry mouth, flatulence, skin rash, fatigue, pain, fever and chills, malaise.

Rare adverse effects (may affect up to 1 in 1,000 people):

Peptic ulcer, peptic ulcer perforation or bleeding (which may manifest with vomiting of blood or black stools), fainting, high blood pressure, slow breathing, blood retention, nausea, vomiting of blood or black stools.(e.g., swelling of the ankles), laryngeal oedema, loss of appetite (e.g., loss of appetite, loss of appetite, loss of appetite, loss of appetite).loss of appetite (anorexia), abnormal sensation, itchy rash, acne, increased sweating, lower back pain, frequent urination, menstrual disturbances, prostatic disturbances, liver function tests, liver function tests, urinary tract infections, urinary tract infections, urinary tract infections.abnormal liver function tests (blood tests), liver cell damage (hepatitis), acute renal failure.

Very rare (may affect up to 1 in 10,000 people):

Anaphylactic reaction (hypersensitivity reaction which may also lead to collapse), ulcers in skin, mouth, eyes and genital areas (yes, in some cases, even in the mouth.(Stevens Johnson syndrome and Lyell syndrome), swelling of the face or swelling of the lips and throat (angioedema), difficulty in breathing due to narrowing of the airways (angioedema).(bronchospasm), shortness of breath, tachycardia, low blood pressure, inflammation of the pancreas, blurred vision, ringing in the ears (tinnitus), sensitive skin, sensitivity to light, itching, kidney problems. Decreased number of white blood cells (neutropenia), decreased number of platelets (thrombocytopenia).

Tell your doctor immediately if you notice any gastrointestinal side effects at the start of treatment (e.g. stomach pain, heartburn or bleeding), if you have previously experienced any of these side effects due to prolonged treatment with anti-inflammatory drugs, and especially if you are an elderly patient.

Stop taking this medicine immediately if you notice the appearance of a skin rash or a lesion inside the mouth or on the genitals, or any other signs of allergy.

Fluid retention and swelling (especially in the ankles and legs), increased blood pressure and heart failure have been reported during treatment with non-steroidal anti-inflammatory drugs.

Medicines such as Endolex may be associated with a small increased risk of heart attack ('myocardial infarction') or stroke ('cerebrovascular accident').

In patients with immune system disorders affecting connective tissue (systemic lupus erythematosus or mixed connective tissue disease), anti-inflammatory drugs may rarely cause fever, headache and stiff neck.

The most commonly observed adverse effects are gastrointestinal. Peptic ulcers, perforation or gastrointestinal bleeding, sometimes fatal, may occur, especially in elderly patients.

Nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, abdominal pain, malena, haematemesis, ulcerative stomatitis, worsening of colitis and Crohn's disease have been reported after administration. Less frequently, inflammation of the stomach wall (gastritis) has been observed.

As with other NSAIDs, aseptic meningitis, which may occur predominantly in patients with systemic lupus erythematosus or mixed connective tissue disease, and haematological reactions (purpura, aplastic and haemolytic anaemia, and more rarely agranulocytosis and marrow hypoplasia) may occur.

• If you are allergic or have had allergy problems in the past;
• If you have kidney, liver or heart disease (hypertension and/or heart failure), or fluid retention or have suffered from any of these diseases in the past;
• If you are taking diuretics or have insufficient hydration and reduced blood volume due to excessive fluid loss (e.g. from excessive urination, diarrhoea or vomiting);
• If you have heart problems, a history of stroke, or think you may be at risk for these conditions (for example, you have high blood pressure, have diabetes, have increased cholesterol, or are a smoker) you should discuss this treatment with your doctor or pharmacist. Medicines such as Endolex may be associated with a small increased risk of heart attacks ('myocardial infarction') or stroke ('cerebrovascular accident'). This risk is more likely to occur with high doses and prolonged treatment. Do not exceed the recommended dose and duration of treatment;
• If you are an elderly patient, you may experience a higher incidence of side effects (see section 4). If these occur, consult your doctor immediately;
• If you are a woman with fertility problems (Endolex may decrease your fertility so you should not take it if you are planning to become pregnant or if you are undergoing fertility tests);
• If you have a blood and blood cell production disorder;
• If you have systemic lupus erythematosus or mixed connective tissue disease (diseases of the immune system that affect connective tissue);
• If you have or have had in the past chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease);
• If you suffer or have suffered in the past from stomach or intestinal disorders;
• If you have chickenpox, as exceptionally NSAIDs may aggravate the infection;
• If you are taking other medicines that increase the risk of peptic ulcer or bleeding, e.g. oral corticosteroids, some antidepressants (of the SSRI type, Selective Serotonin Reuptake Inhibitors), some antidepressants (of the SSRI type, Selective Serotonin Reuptake Inhibitors), some antidepressants (of the SSRI type, Selective Serotonin ReIn these cases, consult your doctor for advice on the use of these drugs. In these cases, consult your doctor before taking Endolex: your doctor may prescribe an additional medicine to protect your stomach (e.g. misoprostol or other medicines that block the production of stomach acid).
• If you suffer from asthma, combined with chronic rhinitis or sinusitis, and/or nasal polyps, as you have a higher risk of allergy to aspirin and/or NSAIDs than the rest of the population. Administration of this medicinal product may provoke asthma attacks or bronchospasm, particularly in patients allergic to acetylsalicylic acid or NSAIDs.

Each sachet of oral solution of this medicinal product contains as active substance 36.90 mg dexketoprofen trometamol, equivalent to 25 mg dexketoprofen.

Excipients also include: ammonium glycyrrhizate, neohesperidine dihydrochalcone, methyl parahydroxybenzoate (E-218), sodium saccharin, sucrose, macrogol 400, lemon flavouring (contains ethanol), povidone, disodium phosphate, sodium dihydrogen phosphate dihydrate, purified water.

If after 4 days of taking Endolex 25 mg oral solution you still have pain, we advise you to see your doctor as soon as possible to have the situation and the pain assessed.

Preferably, we advise you to take this medicine with food to prevent stomach damage, however, if the pain you are experiencing is very intense, you could take it occasionally on an empty stomach so that it can be absorbed more easily.

It would be strongly advised against taking Endolex 25 mg oral solution with alcoholic drinks.

The price of non-prescription medicines is set by law. However, at Farmaciasdirect you can buy ENDOLEX 25 MG COATED PILLS WITH FILM at a discount of up to 10%, which is the legal maximum allowed.