Difenadex 25 Mg 10 Sachets

This medicine is indicated for inflammatory processes. It relieves mild to moderate pain. It is recommended to be taken in cases such as muscle pain, joint pain, back pain, sprains, menstrual pain or dental pain.

This medicine is indicated for adults over 18 years of age.

It is a medicine in sachets, oral solution, which can be taken directly from the sachet itself or stirred in a glass of water. The dose depends on the type of pain, duration and intensity of the same, being the doctor the one to set the dosage in each case.

If allergic to dexketoprofen or to any of the other ingredients of this medicinal product (listed in section 6).
If you are allergic to acetylsalicylic acid or to any other non-steroidal anti-inflammatory drug.
If you have asthma or have had asthma attacks, acute allergic rhinitis (a short period of swelling of the lining of the nose), nasal polyps (fleshy formations inside the nose due to allergy), urticaria (skin rash), angioedema (swelling of the face, eyes, lips or tongue, or difficulty in breathing) or wheezing in the chest after taking aspirin or other non-steroidal anti-inflammatory medicines.
If you have had photoallergic or phototoxic reactions (special form of redness or burning of skin exposed to sunlight) while taking ketoprofen (a non-steroidal anti-inflammatory drug) or fibrates (medicines used to reduce blood fat levels).
If you have peptic ulcer, stomach or intestinal bleeding, or if you have had bleeding, ulceration or perforation of the stomach or intestine in the past.
If you have chronic digestive problems (e.g. indigestion, heartburn).
If you have had stomach or intestinal bleeding or perforation in the past, due to previous use of non-steroidal anti-inflammatory drugs (NSAIDs) used for pain.
If you have chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis).
If you have severe heart failure, moderate to severe kidney failure or severe liver failure.
If you have bleeding disorders or blood clotting disorders.
If you are severely dehydrated (have lost a lot of body fluid) due to vomiting, diarrhoea or insufficient fluid intake.
If you are in the third trimester of pregnancy or breast-feeding.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The possible side effects are listed below according to their frequency.

Since the list is based in part on side effects observed with oral use of tablets, and the oral sachet solution is absorbed more rapidly than tablets, it is possible that the actual frequency of side effects (gastrointestinal) may be higher in the oral sachet solution.



Common side effects (may affect up to 1 in 10 people)

Nausea and/or vomiting, mainly upper quadrant abdominal pain, diarrhoea, digestive disorders (dyspepsia).



Rare side effects (may affect up to 1 in 100 people)

Rotatory sensation (vertigo), dizziness, drowsiness, sleep disorders, nervousness, headache, palpitations, hot flushes, inflammation of the stomach wall (gastritis), constipation, dry mouth, flatulence, skin rash, fatigue, pain, feverish feeling and chills, general malaise.



Rare adverse effects (may affect up to 1 in 1,000 people)

Peptic ulcer, peptic ulcer perforation or bleeding (which may manifest with vomiting of blood or black stools), fainting, elevated blood pressure, slowed breathing, fluid retention and peripheral swelling (e.g, ankle swelling), laryngeal oedema, loss of appetite (anorexia), abnormal sensation, itchy rash, acne, increased sweating, lower back pain, frequent urination, menstrual disturbances, prostate disturbances, abnormal liver function tests (blood tests), liver cell damage (hepatitis), acute renal failure.

If you are allergic or have had allergy problems in the past.
If you have kidney, liver or heart disease (hypertension and/or heart failure), or fluid retention or have suffered from any of these diseases in the past.
If you are taking diuretics or have insufficient hydration and reduced blood volume due to excessive fluid loss (e.g. from excessive urination, diarrhoea or vomiting).
If you have heart problems, a history of stroke, or think you may be at risk for these conditions (e.g., have high blood pressure, have diabetes, have high cholesterol, or are a smoker) you should discuss this treatment with your doctor or pharmacist. Medicines such as Difenadex may be associated with a small increased risk of heart attacks ("myocardial infarction") or stroke ("cerebrovascular accident"). Any risk is more likely to occur when high doses and prolonged treatment are used. Do not exceed the recommended dose and duration of treatment.
If you are an elderly patient, you may experience a higher incidence of side effects (see section 4). If these occur, consult your doctor immediately.
If you are a woman with fertility problems (see section 2, "Pregnancy, lactation and fertility").
If you have a blood and blood cell production disorder.
If you have systemic lupus erythematosus or mixed connective tissue disease (diseases of the immune system that affect connective tissue).
If you have or have had in the past chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease).
If you suffer or have suffered in the past from stomach or intestinal disorders.
If you have an infection; see the heading "Infections" below.
If you are taking other medicines that increase the risk of peptic ulcer or bleeding, e.g. oral corticosteroids, some antidepressants (SSRIs, Selective Serotonin Reuptake Inhibitors), agents that prevent the formation of blood clots such as aspirin or anticoagulants such as Warfarin. In these cases, consult your doctor before taking this medicine: your doctor may prescribe an additional medicine to protect your stomach (e.g. misoprostol or other medicines that block the production of gastric acid).
If you suffer from asthma, combined with chronic rhinitis or sinusitis, and/or nasal polyps as you have a higher risk of allergy to aspirin and/or NSAIDs than the rest of the population. Administration of this medicine may cause asthma attacks or bronchospasm, particularly in patients allergic to acetylsalicylic acid or NSAIDs.

The prices of non-prescription medicines are set by law. In our online pharmacy you can buy this medicine at a discount of 10%, which is the maximum allowed by law.