Opella A.A.S. 500 Mg, 20 tablets

It is a medicine containing acetylsalicylic acid. Depending on its concentration, this active ingredient will have one purpose or another.

In this case, A.A.S. 500 mg is indicated to treat occasional mild to moderate pain and fever.

It is recommended for adults and children from 16 years of age.

This medicine is indicated for oral administration. It is recommended to be taken with water or milk and with meals, especially in those patients who have digestive discomfort. It is not recommended to take it on an empty stomach.

What is the recommended dose?

It is indicated for adults and children from 16 years of age, so the dosage would be 1 tablet every 4 or 6 hours, depending on the intensity of the symptoms.

Up to a maximum of 8 tablets a day.

In other words, it is not advisable to take more than 4 grams of acetylsalicylic acid a day.

• If you are allergic to acetylsalicylic acid, or to any of the other ingredients of this medicine.
• If you have suffered from mastocytosis (generally characterised by urticaria) as severe hypersensitivity reactions (severe exaggerated allergic reaction with flushing, hypotension, tachycardia and vomiting) may occur.
• If you suffer or have suffered from gastric or duodenal ulcer or repeated gastric discomfort.
• If you have had asthmatic allergic reactions (difficulty breathing, choking, bronchial spasm and in some cases coughing or wheezing) when taking medicines to reduce inflammation, acetylsalicylic acid, other painkillers, as well as when taking the dye tartrazine.
• If you have or have ever had asthma or nasal polyps associated with asthma that are caused or increased by acetylsalicylic acid, rhinitis or urticaria.
• If you suffer from haemophilia or other blood clotting problems that predispose you to internal bleeding, have any other bleeding disease or risk of bleeding.
• If you are being treated with medicines to promote blood circulation (oral anticoagulants).
• If you are being treated with methotrexate used at doses higher than 20 mg/week.
• If you have severe liver failure.
• If you have severe kidney failure.
• If you have severe and uncontrolled heart failure.
• If you are under 16 years of age, unless expressly indicated by a doctor, as the use of acetylsalicylic acid has been linked to Reye's syndrome, a rare but serious disease.
• If you are in your third trimester of pregnancy (more than 24 weeks gestation), at doses higher than 100 mg/day.

Like all medicines, this medicine may cause side effects, although not everybody gets them.

Frequent

• Blood disorders: impaired clotting when given at high doses (hypoprothrombinemia).
• Respiratory system disorders: rhinitis, difficulty breathing, shortness of breath.
• Gastrointestinal disorders: nausea and vomiting.

Rare:

• Blood disorders.
• Liver disorders: liver toxicity.
• General disorders: in patients with allergy to acetylsalicylic acid and/or other non-steroidal anti-inflammatory drugs, generalised allergic reactions may occur. This adverse effect may also occur in people who have not previously had problems with allergy to acetylsalicylic acid.

The following adverse effects have been observed after prolonged treatment with acetylsalicylic acid, the frequency of which cannot be established with certainty:

• Gastrointestinal disorders:
  • Inflammation of the oesophagus, duodenum and stomach mucosa, ulceration of the oesophagus, intestinal ulcers, colitis and perforation. These reactions may or may not be associated with bleeding.
  • Acute pancreatitis (inflammation of the pancreas).
  • Pain in the abdomen, dyspepsia, gastric ulcer and duodenal ulcer.
  • Bleeding from the stomach, which may be seen in the stool or cause vomiting of blood.
• Ringing in the ears, deafness.
• Intracranial haemorrhage which can be fatal, especially in elderly patients.
• Confusion.
• Non-cardiogenic pulmonary oedema (fluid accumulation in the lungs without cardiac involvement) with chronic use and associated with allergic reaction due to acetylsalicylic acid, bronchospasm, asthma.
• Fixed rash, itching, accumulation of fluid in skin and mucous membranes, skin reactions.
• Haemorrhagic syndromes: bruising, urogenital haemorrhage, bleeding from the nose, gums, appearance of red spots on the skin. If a cut or wound occurs, bleeding may take a little longer than normal to stop.
• Blood disorders: thrombocytopenia (decreased levels of platelets), pancytopenia (decreased white blood cells, red blood cells and platelets), bicytopenia (decreased levels of two types of cells in the blood).(decreased levels of two types of cells in the blood), aplastic anaemia, bone marrow failure, agranulocytosis (decreased levels of granulocytes, a type of white blood cell): a type of white blood cell), neutropenia (decrease in neutrophils: a type of white blood cell) and leukopenia (decrease in white blood cells). Haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency.
• Increased liver enzymes and liver damage. Chronic hepatitis. Reye's syndrome (in children with febrile processes, influenza or chickenpox).
• Kidney inflammation and other kidney problems.
• Haematospermia (presence of blood in semen).
• Sweating, headache, dizziness and confusion may occur with prolonged high doses.
• Life-threatening bleeding, vasculitis, including Henoch-Schönlein purpura.
• Simultaneous occurrence of cardiac events and allergic reactions (Kounis syndrome).
• Edema (fluid accumulation) with high (anti-inflammatory) doses of acetylsalicylic acid.
• Hypersensitivity reactions, anaphylactic reactions (severe allergic reaction with respiratory distress and even loss of consciousness).

A.A.S. 500 mg consists of the active substance acetylsalicylic acid at a concentration of 500 mg per tablet.

The other excipients are saccharin sodium, mannitol (E 421), maize starch, gum arabic and orange flavour (containing sucrose, maltodextrin, modified maize starch (E 1450), butylated hydroxyanisole (E 320)).

It is advisable to take with meals and not on an empty stomach to prevent gastric discomfort, but it would be particularly inadvisable in patients suffering from any type of digestive discomfort or ulcer.

If symptoms persist for more than 5 days in the case of pain, and 3 days in the case of fever, it is advisable to see a doctor as soon as possible.

The price of non-prescription medicines is set by law. However, at Farmaciasdirect you can buy A.A.S. 500 mg tablets at a discount of up to 10%, which is the legal maximum allowed.